Mobile Clinics and Remote Access will Bring Medical Attention in Real Time

Kallo has deployed its remote health-care delivery system on the IBM cloud to bring advanced real-time medical services to rural areas of the world.

Kallo's mobile health-care systems will be used to build and extend primary care infrastructure in countries including Guinea and Ghana, making health care accessible to everyone. The company's mission is to deliver public health services, manage communicable and infectious diseases such as Ebola, balance health care delivery inequities, and address rural disease and health threats. On-demand telehealth services will be delivered from the company's global command centre in Markham, Ontario and regional command centres in countries of operation.

IBM provides Kallo with technology consulting and services as well as a cloud infrastructure hosted at the recently opened SoftLayer cloud centre in Toronto. The Toronto location is part of IBM's expanding global network of more than 40 centres serving a growing roster of clients looking to move to hybrid cloud computing environments that encompass open integration, data control and unique industry expertise.

"The health-care industry is in a time of accelerating change that needs continual innovation," said John Cecil, Kallo's Chairman and CEO. "IBM's cloud technology enables us to 'reach the unreached' to scale and securely deliver North American standards of health care to some of the world's most remote or underserved populations."

Kallo services include MobileCare, RuralCare, DialysisCare, hospital information systems, tele-health systems, pharmacy information, disaster management, air and surface patient transportation systems and clinical training.

The units work in collaboration with each other, with the mobile and rural clinics providing primary care. Secondary/local specialized care is provided by the regional command centres while the global command centre provides specialized consultative care. With the volume of cases per country and the privacy and confidentiality standards in cross border tele-health practice, plans include dedicated global command centres for each country.

The IBM SoftLayer cloud solution provides increased visibility into the status and dispensation of sensitive medical data. Increasingly, clinicians everywhere are leveraging cloud computing technology – often from mobile devices – as a means to quickly access and share data and knowledge.

"Kallo is a perfect example of how young companies can take their business ideas forward on a scalable, flexible, global cloud infrastructure," said Nevil Knupp, Vice President for IBM Cloud. "Using the cloud to quickly build and bring solutions like Kallo's to market, provides a new level of agility to the way they develop. By delivering more immediate results, they can in turn help alleviate some of the most pressing health issues today."

By deploying its IT environment on the IBM Cloud, Kallo will be able to concentrate on the delivery of health care while IBM manages its IT infrastructure, enabling it to seamlessly protect data and scale with confidence. The reach of SoftLayer's cloud platform is also important for Kallo as the company plans to expand its services globally in developing countries.

Researchers from Dartmouth's Norris Cotton Cancer Center, led by Casey S. Greene, PhD, reported in Pacific Symposium on Biocomputing on the use of denoising autoencoders (DAs) to effectively extract key biological principles from gene expression data and summarize them into constructed features with convenient properties.

"Cancers are very complex," explained Greene. "Our goal is to measure which genes are being expressed, and to what extent they're being expressed, and then automatically summarize what the cancer is doing and how we might control it."

Normally, it is difficult to apply computational models across different studies because the gene expression data is "noisy," meaning that there are many factors that differ in the way gene expression is measured. To begin their analysis, Greene's team added more noise to the data and then trained a computer to remove the noise. To remove the noise, the computer had to learn about key underlying features of breast cancer. "This approach of removing noise makes the models we constructed more generally applicable," Greene said.

Greene and the Dartmouth team studied DAs, which train computers directly on the data without requiring researchers to provide known biological principles to the computer, as a method to identify and extract complex patterns from genomic data. The model that the supercomputer constructs can then be compared to previous discoveries to understand where data supports those discoveries and where the data raises new questions. The performance of DAs was evaluated by applying them to a large collection of breast cancer gene expression data. Results show that DAs were able to recognize changes in gene expression that corresponded to the cancers' molecular and clinical information.

"These techniques and findings will enable others to use the DAs to evaluate gene expression data in a variety of disease sites," reported Greene. "While noise in data is usually viewed as a problem, adding noise to data can actually be a good thing because it can help reveal the underlying signal. When we did this to analyze data from breast cancers, we found gene expression features that generalize across studies and represent important clinical factors."

Next for Greene's research team are more complex models that take multiple levels of regulation into account. Their goal is to develop methods that not only model data but that can automatically explain to researchers what the models have learned.

Secure Technology Enables Real-Time Assessment and Diagnosis at Molecular Level at Point of Care

First Product in Innovative Partnership Transforming Healthcare placing a super-computer in the palm of a doctor’s hand

BlackBerry and NantHealth has announced the first secure clinical genome browser that gives doctors unprecedented access to patients’ genetic data on the BlackBerry Passport smartphone – the NantOmics Cancer Genome Browser.

The NantOmics Cancer Genome Browser platform on the BlackBerry Passport enables deep, interactive reporting on genomics data for physicians and other treatment providers in clinical settings – for example, giving oncologists a powerful view into the individual genetic alternations that make each patient’s disease unique and highlighting relevant treatment options. The BlackBerry Passport’s large high resolution screen enables clinicians to view a patient’s chromosome at an individual base-pair level. It is the first in a series of innovative offerings being developed jointly by BlackBerry and NantHealth for use by healthcare professionals.

“BlackBerry’s partnership with NantHealth illustrates how the mobile security and collaboration technology we are known for can be reimagined to create revolutionary applications across a variety of industries,” said John Chen, Executive Chairman and CEO, BlackBerry. “BlackBerry technology has proven itself secure, reliable and powerful enough to be counted on in life-and-death situations. Its innovative form and functionality make BlackBerry Passport an ideal addition to a doctor’s medical kit.”

“The proprietary NantOmics Cancer Genome Browser enables clinicians for the first time to investigate a tumor genome from the full three billion bases down to the single-base level in real-time, thanks to the power of the NantOmics supercomputing infrastructure,” said Patrick Soon-Shiong, M.D., founder and CEO of NantHealth. “This integrates with NantHealth’s treatment recommendation engine, Eviti, to personalize treatment protocols to individual patients based on their genomic signature.”

Powered by BlackBerry’s mobile security infrastructure, the NantOmics Cancer Genome Browser is fully encrypted to allow deployment in a HIPAA-secured environment, enabling clinicians to securely access patient data as soon as it’s available, wherever they are. BlackBerry’s recently launched BES12 cross-platform EMM solution will enable hospital IT administrators to easily deploy the application to a clinician’s BlackBerry Passport smartphone and ensures that the application data is fully secure end-to-end.

“BlackBerry already powers many of the diagnostic machines clinicians rely heavily upon so it makes sense to tie those devices directly to a BlackBerry smartphone,” said Soon-Shiong. “NantHealth has quietly built the unique capability of placing a supercomputer into the doctor’s hand at point of care and in time of need. Now with BlackBerry’s partnership and through the power of the cloud and secure networks, the reality is we are now able to put dozens of supercomputers, through mobile devices, into doctor’s hands on a global basis. Our goal is to extend this unique capability from doctor to patient, thereby establishing patient empowered 21st century health.”

The NantOmics Cancer Genome Browser will be demonstrated at the Consumer Electronics Show (CES) in January and will be preloaded on BlackBerry Passport devices and available to the professional community in early 2015.

A major investment in gene sequencing technology will secure Scotland’s place as a world leader in a genomics revolution that is set to transform healthcare.

The initiative will enable scientists and clinicians to access equipment that can decode the entire genetic make-up of a person for less than £750.

The Universities of Edinburgh and Glasgow are to partner with Illumina in the £15 million project. The investment will establish The Scottish Genomes Partnership, which will install 15 state-of-the-art HiSeq X sequencing instruments divided between two hubs within the Universities.

Researchers will be able to study the genomes of both healthy and sick people on a large scale and faster than before.

Linking genetic data with clinical information will enable more precise, molecular diagnoses for patients in the Scottish NHS, leading to more personalised treatment and safer selection of drug therapies.

It will also bring new understanding of the causes of both rare and common diseases, opening the door to the development of new treatments.

The Partnership will initially focus on very rapid screening of cancer patients, diagnosing childhood illnesses, disorders of the central nervous system and population studies.

Eventually, by utilizing other Illumina systems, they hope to use the technology to study genomes from plants and livestock for agricultural research, an area at which Scotland excels. They also hope to examine infectious organisms such as bacteria and viruses in order more quickly and accurately to diagnose infections.

The Universities will draw on the Medical Genomics leadership based at the University of Glasgow’s Wolfson Wohl Cancer Centre, a leading-edge translational research facility dedicated to cancer, and the expertise of Edinburgh Genomics, the UK’s largest university-based gene sequencing facility.

Professor Jonathan Seckl, Vice Principal (Research) at the University of Edinburgh, said: “Scotland is uniquely placed to make a significant contribution to the field of genomics medicine. It has well established and approved methods of linking electronic health records to medical research programmes, governed by NHS and academic regulations.

“Edinburgh is also home to the UK’s national supercomputer facility, which will provide the high performance data processing ability needed to analyse the vast volume of information that will be generated from this research. This affords an exceptional opportunity for Scotland’s outstanding researchers and clinicians to transform the way medicine is practiced in the coming years.”

Professor Anna Dominiczak, Vice Principal and Head of College of Medical, Veterinary and Life Sciences at the University of Glasgow, said: “Scotland has an ideal ecosystem to lead the world in precision medicine. With a population of 5.3 million, cohesive and collaborative NHS, academia and industry, we have developed unique capability to screen DNA from patients with cancer, rheumatoid arthritis and other inflammatory and infectious diseases.

“This will add significant value to Glasgow’s investment in the South Glasgow University Hospital and will allow us to select the best treatment for individual patients.”

Jay Flatley, CEO of Illumina, said: “We are very excited to work with The Universities of Edinburgh and Glasgow as they create The Scottish Genomes Partnership and are committed to working closely with them on this ground-breaking initiative. By unlocking the power of the genome, we can better understand cancer and rare diseases and ultimately transform how they are diagnosed and treated.”

OhioHealth is utilizing technology to connect patients with physicians. By using services from Time Warner Cable Business Class, the organization is able to remotely provide care to patients throughout the state.

While OhioHealth turns to TWCBC for a number of business solutions, including video, phone and data services, it’s TWCBC’s robust network that makes OhioHealth’s cutting-edge telemedicine program possible. TWCBC provides 100 Mbps point-to-point Ethernet Private Line (EPL) fiber circuits connecting 50 care sites, 300 Mbps Dedicated Internet Access (DIA) at their headquarters, plus up to 100 Mbps High Speed Internet Access service connecting the organization’s smaller offices. This gives OhioHealth the speed and capacity for applications such as streaming two-way audio and video.

“A patient and physician no longer have to be sitting together in the same room. A physician can provide evaluation and diagnosis through the technology that’s available today,” said Jim Lowder, system vice president, technology, OhioHealth, which has 11 member hospitals, more than 50 ambulatory and surgery centers, primary care and specialty practices. “Having a high speed, high performance, highly reliable, low latency network is absolutely critical to our operations. Time Warner Cable Business Class provides that network connectivity.”

One example is OhioHealth’s eICU. Skilled ICU “intensivists” at a central metropolitan facility can now remotely monitor critical patients in hospitals that lack 24-hour access to on-site specialized ICU staff.

Another example is the OhioHealth Stroke Network, which connects emergency teams at community hospitals to specialists in critical care and stroke at OhioHealth’s facilities in Columbus, Ohio. TWCBC’s fiber-based EPL and DIA solutions have expanded the reach of the OhioHealth Stroke Network by utilizing real-time, two-way audio and video, as well as access to imaging, to ensure stroke patients quickly receive the appropriate treatment and interventions.

“OhioHealth is a true innovator and leader. The organization's use of technology to increase patient care effectiveness can help save lives,” said Jeff Greenberg, group vice president, mid-market, channels and alliances, Time Warner Cable Business Services.

TWCBC also provides support beyond the solutions. The company helps OhioHealth with requirements for system availability, disaster recovery and redundancy. The organization has implemented a redundancy solution that features true route diversity, separate entrance facilities and failover supported by ring architecture.

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