SCIENCE

• The guarantee CESGA servers and storage analysis Studies in the FPGMX ultrasecuenciadores.
• Xenómica Foundation has had in its capacity forecasts Virtual supercomputer calculation Gallego.  

Today, the President of the Center Galicia Supercomputing, CESGA, and General Director of R & D + i of the Xunta de Galicia, Ricardo Pueyo Chapel and the Director of the Galician Public Foundation Xenómica Medicine, FPGMX, and professor at the USC, Angel Carracedo, presented at the CESGA "Collaboration Agreement for the Commissioning Service ultrasecuenciación Production complete genomes. " The agreement will facilitate the analysis and data storage extracted genetic technologies NGS (Next Generation Sequencing), allowing analyze large regions of the genome, exome and complete genomes. New ultrasecuenciadores of FPGMX as supercomputers are CESGA available to all researchers in Galicia.  

Among other advantages, the cooperation agreement offers the possibility of reducing costs some types of genetic analysis, making viable the implementation of a number of other evidence, so far, proved intractable.   In this sense, Ricardo Capilla said: "We want the public schools, both as research technology, demonstrating its ability to support its quality path investigating the ability to develop more services to citizens. This is especially interesting when, as in this case, the improvement of the area health. "  

The huge amount of data generated annually multiplied ultrasecuenciación ten storage needs and current analysis, exceeding systems capabilities Xenomica Foundation, which need to perform costly infrastructure investment calculation, mass storage and data advanced communications, you can not have the resources CESGA. The FINISTERRAE supercomputer, the Science and Technology of Galicia, and the new RECETGA SVG (Virtual Supercomputer Gallego), guarantee the continuity of this research.  

Servers Using CESGA

The agreement includes the amount of information to transfer between teams and CHUS CESGA (about 1000 GB per month), the computation times (About 2 or 3 days per analysis), storage of results time for consultation by researchers on different computing resources additional CESGA, backups and archiving tapes.  

The results of the two types ultrasecuenciadores require further analysis, the most urgent assembly was tested in the virtual cluster covered by the agreement. Those variability was analyzed in the SVG.  

Each race ultrasecuenciador generates an average volume of data between 500 and 700 Gigas. Move this amount of information between the two centers is possible by network connection RECETGA exclusive, with a line 1Gbps Fiber Optic stretched between the CHUS and CESGA.    

Benefited pathologies

The ultrasecuenciación is a next-generation technology that can work with data massive sequencing. Represents a quantum leap over previous technologies sequencing and genotyping because, although the study base is always variability human (for the differences in the genes of a person regarding a dispute or case compared to a control) the advantage provided by NGS is that they allow to see whole genome and therefore all differences to be studied.  

As explained by Angel Carracedo, NGS technology will benefit directly knowledge about "all genetically heterogeneous diseases such as genetic cardiac disease (sudden death in young) or retinal dystrophies (common cause of blindness). Genes also have very large as those causing familial colon cancer and breast cancer. Finally, patients diagnosed, because there was no causal gene, will benefit by facilitating discovery of new genes. "  

Collaboration Model

Xenómica Foundation, co-dependent Sergas in the diagnostic field, offers a portfolio analysis services of Genomic Medicine at the diagnosis of diseases, very competitive and recognized nationally and internationally and particularly powerful in lines for colorectal cancer, psychiatric diseases and pharmacogenetics. The years of experience in this group research provides an overview of Genomic Medicine, which is essential when deciding which lines of work.  

For his part CESGA also possesses the technological capability, experience and know of its technicians, to final offer expert solutions when the needs of different research groups that use it. According to Angel Carracedo, have a CESGA center as the research available to Galician, "he takes away a weight at this time is the limit with other groups, similar to ours, are to make progress. "

Ricardo Capilla summarized the collaboration between the two institutions as "a model applied research, competitive, collaborative and self-worth to generate wealth and growth, which will expand services of value to citizenship in the area health. "